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Most people know the Kindle as a hardware ebook reader, but Amazon have released the Kindle software for PC and Mac. Kindle for PC came out in late 2009, and Kindle for the Mac was made available in March 2010. While they included some accessibility features, a big drawback was the lack of speech access to book content.
Update, June 2011: A new version of Kindle for PC, which includes a text-to-speech engine, was released in May 2011.