Post date: 
Friday, 12 June 2015

Two new developments, of very different kinds, are on the horizon for glaucoma patients, reports Radhika Holmstrom.

Around one in 50 people over 40 in the UK is estimated to have glaucoma; and if the condition is caught early enough, it’s entirely treatable. The main campaigns, therefore, are usually urging the surprisingly large number of people who do not have regular eye checks to get themselves to the optician as soon as possible – ideally at the stage when their vision isn’t yet perceptibly affected.

The treatment bottleneck

However, even when people are in the system for treatment, they often come up against logistical problems. As with many other eye conditions, they hit a bottleneck: with their appointments delayed, cancelled and held over for a considerable length of time. “Being seen on time – often six-monthly or more frequently –  is really important for glaucoma but quite often we get calls from patients, either through the helpline or directly to us, whose appointments have been delayed. It’s not an issue of initial referrals to hospital, but of follow-up appointments,” says RNIB assistant policy and campaigns officer Victoria Armitage Assistant. “One patient was told to come back in six months, and had been waiting a year. Often what happens is that an appointment doesn’t arrive in the post, and they’re told to wait. And it’s probably only the minority who follow it up or get in touch with us.”

“Because glaucoma happens to an ageing population, the number of patients we see continues to expand. At Moorfields there has been a 15 per cent increase between 2009 and 2012. That is an increasing pressure. Often patients’ appointments may be rescheduled, and quite a number will miss an appointment too,” says John Brookes, consultant ophthalmologist and glaucoma specialist at Moorfields Hospital, London.

“In the early stages patients don’t feel that there is anything wrong with them. We’ve also found that many of the patients who miss appointments are fairly vulnerable people, who wouldn’t re-contact the hospital by themselves,” he adds.

This has been the case for some time. In fact between 2005 and May 2009, the NHS’s National Reporting and Learning Service received reports of 44 glaucoma patients whose sight deteriorated – including 13 who went blind in one or both eyes – as the result of delayed follow-up appointments.

As a result, the National Institute for Health and Care Excellence (NICE) issued new guidance; but this is clearly not always being adhered to. “In 2012 we asked 125 hospital trusts, and found 50 to 70 per cent didn’t have the records of how many appointments were delayed,” says Armitage. “After that we contacted some of the hospital trusts which did have that information, and worked with them to see how the situation could be remedied overall.”

The results, based on work with Brookes as well as consultants from Manchester Royal Eye Hospital and Royal Hallamshire Hospital, Sheffield, have formed a submission to NICE on how to improve practice.

There are two key points. One is to make sure clinic clerks have a basic understanding of glaucoma, and the importance of getting prompt appointments even if the patients’ sight does not seem to be changing.  The other is to ensure that patients themselves know when they should be seen and what to do about cancelled or delayed appointments (and in addition, patients may benefit from learning how to monitor their own intraocular pressure).

The breakthrough

There’s also a good chance that the treatments themselves may change in future, as new research generates new evidence about the way the disease operates. In particular, Harminder Dua, professor of ophthalmology and visual sciences at the University of Nottingham, has discovered a new and distinct layer deep in the tissue of the cornea which may impact on the understanding of glaucoma.

‘Dua’s layer’ is made up of thin plates of collagen and sits at the back of the cornea; and recently Dua and his colleagues have demonstrated that this layer also continues at the periphery as part of the trabecular meshwork. The fibres of the newly identified layer branch out to form the meshwork, and the cells of the trabecular meshwork populate the new layer for about half a millimetre into the periphery of the cornea.

It looks as if the trabecular meshwork begins to form in the corneal periphery at a much earlier point than was previously thought. For glaucoma, that has particular implications for the significant number of people who have surgery – but also for thinking about how the condition operates more generally.

“Identifying these different types of tissues will change our thinking on the meshwork and on how the cornea could contribute to the stresses and strains which the meshwork experiences,” Dua explains. “Every heartbeat, every blink, puts stress on the cornea and this is likely to be passed on to the trabecular meshwork. Given the significance of the meshwork in glaucoma, it’s possible that such stresses and strains will come into the thinking about glaucoma, and will also explain partly why so many people with a corneal transplant develop glaucoma.

"These theories and hypotheses need to be subjected to scientific rigour, and then we’ll come up with answers. I’m sure a lot of people will be looking at ways of researching this.” 

Press for treatment

At the moment, though, the crucial thing is to get the existing treatments as early as possible, and as frequently as necessary. “We’ve got on top of this in a number of different ways, but these need to be kept going. If they’re not, the problem will recur,” Brookes points out. “People feel as if they’re making a fuss, but it is worth doing” Armitage concludes. “This is too important to put on hold.”

The condition

The term glaucoma covers a number of different eye conditions in which the optic nerve is damaged at the point where it leaves the eye. Often – although not always – at least part of this damage is caused by an increase in ‘eye pressure’, either because the eye has produced too much aqueous fluid or because it cannot drain away this fluid properly through the trabecular meshwork, a wedge-shaped ‘sieve’ made of beams of collagen, through which the aqueous fluid of the eye drains out.

Primary open angle glaucoma is the most common type in the UK and other Western countries. It is caused by a slow rise in pressure and initially has no apparent effects, even though it is causing irreparable damage. It is usually treated with medication to reduce the eye pressure, taken in the form of eye drops. Some patients may go on to have laser treatment or even a small operation to drain fluid away from the eyeball. Any damage which has been done to the optic nerve over time cannot be reversed, but it can be halted

Acute angle closure – or ‘acute’ glaucoma – comes on very differently, because it’s caused by a sudden sharp increase in pressure and is often very painful. Most people need laser treatment and/or surgery in addition to drug treatment – and to need it in both eyes, as there is a high risk the other eye will develop the same problem; but on the other hand this often makes it possible to restore almost complete vision, because the optic nerve has not been subjected to long-term damage.

Managing glaucoma patients

By 2013 over 90 per cent of patients at the Manchester Royal Eye Hospital were receiving their outpatient appointments at the appropriate review interval. Cecilia Fenerty, consultant ophthalmologist at Manchester Royal Eye Hospital, who worked on the NICE submission, describes the way that the hospital now manages glaucoma patients.

“The first challenge is to quantify the caseload, and that can be quite difficult because patients with glaucoma may be seeing other ophthalmic consultants, not just glaucoma specialists. After that, it’s all about stratifying the risk or severity of the disease so we could allocate patients appropriately.

“Lower-risk patients start with the glaucoma evaluation clinic, a virtual clinic which is a one-stop-shop which leads to a personalised letter, where all the information has been reviewed by a consultant. We can inform them about the next step, whether that is no appointment, a follow-up appointment, or anything else.

"A step up from that is the lower-risk patients who are treated in the assessment clinic, staffed by trained optometrists who all have or are working towards a diploma and are managed under consultant supervision. Then the step up from that is the higher risk patients with advanced glaucoma, who are seen within the consultant-led clinic.

“That’s using our resources and the skill mix as best we can. We also have a day phasing service where intraocular pressure can be assessed, and some people are loaned home eye care equipment as well, which empowers them to see their own pressures throughout the day.”

Useful resources

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